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EPISODES 66LATEST SEP 18, 2026HOST JARED ISAACMAN

Topics covered

Competitive Strategy Geopolitics Venture Capital AI Infrastructure Regulation & Policy Large Language Models AI Safety AI Agents Capital Efficiency Leadership & Management Fundraising & Venture Capital Enterprise SaaS

Jared Isaacman: A New Era for NASA and American Space Exploration

Brad Gerstner: No AI Bubble, Semis Eat the Nasdaq & AI's Take Off Problem

Meta's Dina Powell McCormick: The Case for Data Centers, Backlash, AI Job Boom & Meta's Future

CHAMATH PALIHAPITIYA, DINA POWELL MCCORMICK, UNKNOWN SPEAKER 00, UNKNOWN SPEAKER 01, UNKNOWN SPEAKER 03, UNKNOWN SPEAKER 04, UNKNOWN SPEAKER 06, UNKNOWN SPEAKER 08, UNKNOWN SPEAKER 09, UNKNOWN SPEAKER 12

Elon Musk & Gwynne Shotwell on AI Risks and Peer Review, Starship, Terafab, SpaceX/Tesla Merger

ELON MUSK, GWYNNE SHOTWELL

JD Vance on AI, Entitlement Fraud, Iran War, Israel, H-1B Abuse & the Midterms

Satya Nadella on the AI Doomer Slowdown, Microsoft's Master Plan & Who Wins AI

CHAMATH PALIHAPITIYA, SATYA NADELLA

AI Kills Everybody or Doomer Psyop? OpenAI's Math Breakthrough, Nike's $200B Collapse

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

GPT-6 Hits AGI? Tech Euphoria 2.0, SF Mansion Shortage, NYC Bans AI in Schools & Venezuela Oil Deal

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

Nvidia's Historic Quarter, SaaS Comeback, Bessent vs Druck, America's Debt Crisis, Cancer Vaccine

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, JASON CALACANIS, JASON SACKS, JASON SACKS (GUEST/EXTRA)

Eric Weinstein: The State of American Science, Breakthrough Coverups, and the Danger of Physics

CHAMATH PALIHAPITIYA, ERIC WEINSTEIN

Michael Kratsios: Trump's Science Agenda, Anti-Science Claims, Fauci's Damage, DEI & China

MICHAEL KRATSIOS

Flock CEO Garrett Langley on Controversy, "Surveillance State" Claims, and Privacy vs Safety

CHAMATH PALIHAPITIYA, GARRETT LANGLEY

Anthropic's $2T IPO, Zuck's AI Manifesto, Nvidia's $500B AI Bet, Grok's Comeback

DAVID SACKS, GAVIN BAKER

Rahm Emanuel: Trump's Foreign Policy, China, Europe's Decline, Immigration & DSA vs Democrats

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, JASON FRIEDBERG, RAHM EMANUEL

Google's AI Brain Drain, SpaceX's Huge Quarter, Airtable's 90% Collapse, US Data Fuels China AI

BRAD GERSTNER, DAVID FRIEDBERG, DAVID SACKS

Saronic Founders: Autonomous Warships, China's 230X Advantage & Swarms of Robot Ships

CHAMATH PALIHAPITIYA, DAVID SACKS, DINO MAVRUCAS, VIB ALTAKAR

Chip Stocks Crash, $20B Fund Margin Called, Frontier Labs: SLOW DOWN AI, Mamdani's Grocery Stores

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

The $1/Hour Worker: Four Robotics CEOs on Humanoids at Home, China's Threat, and the End of Dangerous Jobs

AMANDA MCMASTER, BERND BORNICK, DR. PÉTER FANKHAUSER, JASON CALACANIS, JONATHAN HURST, PÉTER FANKHAUSER

The Fight Over Open Source AI, Anthropic's $1.5B Payout, NYC Socialists: Evictions = Violence?

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

Mark Cuban on the AI Bubble: Who Actually Gets Wiped Out?

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, MARK CUBAN

Can the AI Industry Regulate Itself? Stripe Wants PayPal, China Catches Up, NY Bans Datacenters

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, NICK

Former Intel CEO on What Went Wrong, What's Next + Lovable CEO on the Real Promise of Vibe Coding

ANTON OSIKA, JASON CALACANIS, JENSEN (DIALOGUE REFERENCE), PAT GELSINGER

The Trillion-Dollar Industries AI Is Disrupting: Voice, Law & the End of the Billable Hour

DAVID SACKS, JASON CALACANIS

AI Sovereignty Wars, Palantir-Nvidia Deal, SCOTUS Birthright Ruling, Newsom's CA Budget Lie

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

Nate Silver Predicts: Democrats Take the House, Newsom Is Fading & AOC Might Win It All in 2028

CHAMATH PALIHAPITIYA, DAVID SACKS, JASON CALACANIS, NATE SILVER

Socialists Sweep NYC, China Catches Up in Coding, AI Memory Crunch, Micron's Blowout Quarter

GAVIN BAKER, TRAVIS KALANICK

GameStop CEO Ryan Cohen's $56B Plan to Take Over eBay

CHAMATH PALIHAPITIYA, DAVID SACKS, JASON CALACANIS, RYAN COHEN

World's First Trillionaire, Anthropic Fable Banned, The New Oligarchs, Iran Peace Deal

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, SPEAKER_00, SPEAKER_03, SPEAKER_04, SPEAKER_06

Anthropic's Fable Backlash, Nationalizing AI, Inflation Heats Up & California's Broken Elections

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, SARAH FRIAR, SPENCER PRATT, THOMAS LAFONT

All-In's Best Ideas Pitch Competition: 4 Investors Present Their Top Trades Live

AARON COWEN, CHAMATH PALIHAPITIYA, DAN DREYFUS, DAVID FRIEDBERG, DAVID SACKS, GAVIN BAKER, JASON CALACANIS, KYLE SIMANI, OLEG NODELMAN

Dan Dreyfus: America's Critical Minerals Crisis is Here

CHAMATH PALIHAPITIYA, DAN DREYFUS, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

Senators John Fetterman and Dave McCormick: Bipartisanship, Money in DC, Datacenters, Graham Platner

CHAMATH PALIHAPITIYA, DAVE MCCORMICK, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, JOHN FETTERMAN

Bill Maris: How Google Could Crush AI Competitors, Why Small Funds Win, and AI's Atari Stage

BILL MARIS, CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, SACKS

Nikesh Arora: Mythos is Real, Analytical SaaS is Dead, and Google can be a $10T company

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, NIKESH ARORA, SARAH

Inside the Private Stock Market Boom: SpaceX, Anthropic, OpenAI & the Rise of Secondaries

BRAD GERSTNER, CHAMATH PALIHAPITIYA, DAVID SACKS, GAVIN BAKER, JASON CALACANIS, KELLY RODRIQUES

The IPO Comeback: Why Tech Giants Are Finally Going Public | All-In Liquidity IPO Panel

ANDREW FELDMAN, BRAD GERSTNER, CHAMATH PALIHAPITIYA, WILL MARSHALL

Dan Loeb: The Lost Art of Short Selling, and Why Stock Picking is Back

Thomas Laffont: The $4T AI IPO Wave, 2026's Unicorn Economy, and the 10X Paradox

CHAMATH, CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

Bill Ackman: Investment Strategy, What the Market is Missing, How AI Breaks Businesses

BILL ACKMAN, CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

OpenAI CFO Sarah Friar on IPO, AI Rivalries, New Device, and Spending $100B+ on Compute

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, SARAH FRIAR

Pope vs AI, Anthropic's Digital God, AI Job Loss Narrative Flips, Open Source Crackdown Coming?

BILL GURLEY, CHAMATH PALIHAPITIYA, JASON CALACANIS

SpaceX's $2T Case, Nvidia's Shock Selloff, America Turns on AI, Trump Pulls AI Order, Bond Crisis?

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, FRIEDBERG, GAVIN BAKER, JASON CALACANIS, SACKS

Trump-Xi Summit, Benioff: "Not My First SaaSpocalypse," OpenAI vs Apple, Multi-Sensory AI, El Niño

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, JASON CALACANIS, MARC BENIOFF

Charles & Chase Koch on How They Quietly Built a $150B Empire

CHARLES KOCH, CHASE KOCH

OpenAI Misses Targets, Codex vs Claude, Elon vs Sam Trial, Big Hyperscaler Beats, Peptide Craze

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACHS, JASON CALACANIS

CA Governor Candidate Steve Hilton on Why California is Destroying Itself & How a Republican Can Win

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, STEVE HILTON

SpaceX-Cursor Deal, SaaS Debt Bomb, New Apple CEO, SPLC Indictment, Colon Cancer Spike

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, UNIDENTIFIED (APPEARS BRIEFLY), UNIDENTIFIED (BRIEF)

OpenAI's Identity Crisis, Datacenter Wars, Market Up on Iran News, Mamdani's First Tax, Swalwell Out

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, TRAVIS KALANICK

Anthropic's $30B Ramp, Mythos Doomsday, OpenClaw Ankled, Iran War Ceasefire, Israel's Influence

BRAD GERSTNER, CHAMATH PALIHAPITIYA, DAVID SACKS, JAMAL PALIAPATI, JASON CALACANIS

Josh Shapiro on Trump, Iran War Chaos, Israel's Failure, the Economy, and 2028 Race

DAVID SACKS, JASON CALACANIS, JOSH SHAPIRO

The Companies Changing Warfare Forever: Palantir & Anduril Execs on Drones, AI & the Future of War

DAVID FRIEDBERG, SHYAM SANKAR, TRAE STEPHENS

SpaceX IPO, Iran War Fallout, Quantum Bitcoin Hack, The Space Opportunity

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, JASON CALACANIS

Anthropic's Generational Run, OpenAI Panics, AI Moats, Meta Loses Lawsuits

CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS

Are Psychedelics the Key to Living Forever? (ft. Bryan Johnson)

BRYAN JOHNSON, DAVID FRIEDBERG, UNIDENTIFIED HOST/PARTICIPANT

Four CEOs on the Future of AI: CoreWeave, Perplexity, Mistral, and IREN

ARAVIND SRINIVAS, ARTHUR MENSCH, DANIEL ROBERTS, JASON CALACANIS, MICHAEL INTRATOR

How Matt Mahan Thinks He Can Save California

DAVID SACKS, MATT MAHAN

Jensen Huang LIVE: Nvidia's Future, Physical AI, Rise of the Agent, Inference Explosion, AI PR Crisis

BRAD GERSTNER, CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, JENSEN HUANG

John Fetterman: The Rogue Democrat Who Broke Party Ranks

DAVID FRIEDBERG, JOHN FETTERMAN

Travis Kalanick & Michael Dell Live from Austin, Texas

BRAD GERSTNER, CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS, JASON CALACANIS, MICHAEL DELL, TRAVIS KALANICK

Iran War, Oil Shock, Off Ramps, AI's Revenue Explosion and PR Nightmare

BRAD GERSTNER, CHAMATH PALIHAPITIYA, DAVID SACKS, JASON CALACANIS

Tucker Carlson: Rise of Nick Fuentes, Paramount vs Netflix, Anti-AI Sentiment, Hottest Takes

CHAMATH PALIHAPITIYA, DAVID SACKS, JASON CALACANIS, TUCKER CARLSON

OpenAI's Code Red, Sacks vs New York Times, New Poverty Line?

JASON CALACANIS, CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, DAVID SACKS

Epstein Files Fallout, Nvidia Risks, Burry's Bad Bet, Google's Breakthrough, Tether's Boom

JASON CALACANIS, DAVID SACKS, CHAMATH PALIHAPITIYA, UNIDENTIFIED/UNKNOWN

Home Affordability Crisis, Palantir's Advantage, Big Short on AI, H-1B Abuse, Solar Storm Hits Earth

GOOGLE AI INFRASTRUCTURE REPRESENTATIVE, GOOGLE AI INFRASTRUCTURE REPRESENTATIVE, CHAMATH PALIHAPITIYA, DAVID FRIEDBERG, JASON CALACANIS

Does OpenAI Need a Bailout? Mamdani Wins, Socialism Rising, Filibuster Nuclear Option

Elon Musk: OpenAI Betrayal, His Future at Tesla, and the Next Big Thing — Grokipedia

ELON MUSK, DAVID SACKS, DAVID SACKS, JASON CALACANIS