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The a16z Show

EPISODES 156LATEST OCT 20, 2026HOST BEN HOROWITZ, ERIK TORENBERG, JAY RUGHANI, KARAN SINGHAL, MARC ANDREESSEN

Topics covered

Competitive Strategy AI Agents Product & Design Large Language Models AI Safety Leadership & Management Go-to-Market & Sales AI Infrastructure Deep Learning Startup Advice Enterprise SaaS Venture Capital

What Happens When Everyone Has a Health Expert in Their Pocket? | OpenAI’s Karan Singhal

BEN HOROWITZ, ERIK TORENBERG, JAY RUGHANI, KARAN SINGHAL, MARC ANDREESSEN

What Happens When Al Agents Can Spend Your Money?

ALEX RAMPELL, BEN HOROWITZ, ERIK TORENBERG, JEAN-DENIS GREZE, MARC ANDREESSEN

Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone

BEN HOROWITZ, ERIK TORENBERG, MARC ANDREESSEN, MARINA MOGILKO, MARIO MARTONE

Why AI Could Finally Fix Healthcare Access | Zocdoc CEO Oliver Kharraz

BEN HOROWITZ, ERIK TORENBERG, JULIE YOO, MARC ANDREESSEN, OLIVER KHARRAZ, PODCASTER

AI Can Write the Code. Can It Run the System? | Grepr CEO Jad Naous

BEN HOROWITZ, ERIK TORENBERG, JAD NAOUS, MARC ANDREESSEN, MARTIN CASADO

When AI Agents Start Spending Your Money | Alex Rampell & Terry Angelos

AD NARRATOR, ALEX RAMPELL, BEN HOROWITZ, ERIK TORENBERG, MARC ANDREESSEN, TERRY ANGELOS

Can Open Models Keep Up With the AI Frontier? | Nathan Lambert

BEN HOROWITZ, ERIK TORENBERG, JENSEN HUANG, LISHA LI, MARC ANDREESSEN, NATHAN LAMBERT, PODCAST OUTRO

Can AI Break Cryptography? What the Experts Actually Think

AD NARRATOR, BEN HOROWITZ, DAN BONEH, EDDY LAZZARIN, ERIK TORENBERG, JUSTIN THALER, LIZ HARKAVY, MARC ANDREESSEN

The Race to Recursive Self-Improving AI

BEN HOROWITZ, DHAVAL ADJODAH, ERIK TORENBERG, MARC ANDREESSEN, MARTIN CASADO, OWEN HE

Nick Bostrom: How Should We Navigate Superintelligence?

AD NARRATOR, BEN HOROWITZ, ERIK TORENBERG, MARC ANDREESSEN, NICK BOSTROM, SOFIA PUCCINI, THEO JAFFEE

What Makes a Great Entrepreneur? | Ben Horowitz on Vintage x Vintage

ALI, BEN HOROWITZ, JAMES NORMAN

Chips, Memory, and Power | Pat Gelsinger

GUIDO APPENZELLER, PAT GELSINGER, RAGHU RAGHURAM

Building the Cloud for an Agentic World | AWS CEO Matt Garman

MATT GARMAN, RAGHU RAGHURAM

How Valon Rebuilt a $13 Trillion Industry From Scratch

ANDREW WANG, ANGELA STRANGE, LINDA DU

Building Defense for the Agentic Era: Kevin Mandia

DAVID GEORGE, KEVIN MANDIA

The Top 100 Consumer AI Apps: Who’s Actually Paying?

ELENA BURGER, JOSH ELLMAN, OLIVIA MOORE, STEVEN SINOFSKY

David George & Jack Altman on AI, Autonomy, and the Next $25 Trillion

DAVID GEORGE, JACK ALTMAN

Beyond the God Model | Alex Atallah & Amjad Masad

ALEX ATALLAH, AMJAD MASAD, ERIK TORENBERG

Why AI Agents Can Beat the Incumbents

ELENA BURGER, SEEMA AMBLE, VLADIMIR KEIL

Rebuilding the Internet for Privacy | Barrett Lyon on DoxxNet

BARRETT LYON, JOEL DE LA GARZA, JOEL DE LA GARZA

The $1 Trillion AI Buildout | State of Markets

ALEX IMMERMAN, DAVID PAWLAN, SANTIAGO RODRIGUEZ, SARAH WANG

The Personal Agent Race Is Here | Anish Acharya & David Pawlan

ANISH ACHARYA, DAVID PAWLAN

AI Can Write Code. Why Isn’t Software Better?

BEN HOROWITZ, DIOGO ALMEIDA, MARTIN CASADO

Building a Team at AI Speed | Harvey’s Maggie Landers

KATIE BURKE, MAGGIE LANDERS

Aaron Levie, Steven Sinofsky & Martin Casado: How Do You Secure a World of AI Agents?

AARON LEVIE, ERIK TORENBERG, MARTIN CASADO, STEVEN SINOFSKY

The Reputation Graph of Silicon Valley | Introducing Cosign

DAVID BOOTH, ERIK TORENBERG, JOSH ELMAN, OLIVIA MOORE

The Case Against an AI Pause | Eddy Lazzarin

EDDY LAZZARIN, THEO JAFFEE

Amjad Masad on Rethinking College for the AI Era

AMJAD MASAD, ERIK TORENBERG, GAGAN BIYANI, UNKNOWN SPEAKER 1

Why a16z is Building a New School for the AI Era | Ben Horowitz

BEN HOROWITZ, ERIK TORENBERG, GAGAN BIYANI

AI Safety Language Is Destroying the Debate | Steven Sinofsky

SOFIA PUCCINI, STEVEN SINOFSKY, THEO JAFFEE

Nas, Grandmaster Caz, Steve Stoute & Ben Horowitz on Paying Hip-Hop’s Pioneers Their Due

BEN HOROWITZ, ERIK TORENBERG, GRANDMASTER CAZ, NAS, STEVE STOUTE

What Makes a Consumer AI Product Stick? | Josh Elman

JOSH ELMAN, OLLIE FORSYTH

Databricks CEO on AI Pacing, Cyber Risk, and the Enterprise

ALI GHODSI, MARTIN CASADO, SARAH WANG

The Next Frontier of AI Video Is Control

BATUHAN TASKAYA, GORKEM YURTSEVEN, JENNIFER LI

The AI-Native CRM

ALEX RAMPELL, JOE SCHMIDT, KEITH PEIRIS

The Age of Body Futurism | Ruby Justice Thelot

ELENA BURGER, RUBY JUSTICE THELOT

Greg Brockman on Why OpenAI Says We’re Entering the AGI Era

BEN HOROWITZ, ERIK TORENBERG, GREG BROCKMAN

World Models, Robotics, and the Future of 3D AI

JUSTIN JOHNSON, SOFIA PUCCINI, THEO JAFFEE

Why Companies Are Becoming a Series of Loops | Anish Acharya on Lenny’s Podcast

ANISH ACHARYA, LENNY RACHITSKY

What It Takes to Build a Startup | Andrew Chen & Matt Perault

ANDREW CHEN, ANDREW CHEN (GUEST/HOST INTERACTION), MATT PERAULT

How AI Is Rewriting the Power Law of Venture Capital

ARAM VERDIYAN, DAVID GEORGE, HOST, JEN KHA

Who Grades the AI Models? | Ben Horowitz & Rayan Krishnan

BEN HOROWITZ, ERIK TORENBERG, JENNIFER LI, RAYAN KRISHNAN, UNKNOWN HOST 02

OpenAI Researchers on the Future of Mathematical Reasoning

LEISHA LI, MARK SELLKE, MEHTAAB SAWHNEY

Can Open Source Keep AI Power From Concentrating?

LUCAS KAISER, SOFIA PUCCINI

Your AI Doctor Is Coming | Julie Yoo

JULIE YOO, SOFIA PUCCINI

Aaron Levie on Why Open AI Wins

AARON LEVIE, SOFIA PUCCINI, THEO JAFFEE

Fei Fei Li: The Race to Build World Models For AI

BEN MILDENHALL, FEI FEI LI, JUSTIN JOHNSON, MARTIN CASADO

The $100B Niches Hiding Inside Payments

ALEX RAMPELL, ERIK TORENBERG, MAX LEVCHIN

Inside Moderna’s Personalized Cancer Vaccine

JORGE CONDE, ROY, STEFAN BANCEL

Daniel Litt: The Mathematician's Guide to AI

DANIEL LITT, LEISHA LI

Gavin Baker: Why AI Demand Is Outrunning Compute Supply

DAVID GEORGE, GAVIN BAKER

Why a16z Launched the Machine Age Fund | Jen Kha

JEN KHA, SOPHIA DEW, THEO JAFFEE

Why 1,200 AI Agents Started Working Together | Ryan Greenblatt

AJAY AKHOTRA, RYAN GREENBLATT, THEO JAFFEE

The Infrastructure Behind the Machine Age

BEN HOROWITZ, ERIK TORENBERG, MARTIN CASADO, RAGHU RAGURAM, SPEAKER_04

Inside Cursor: The Anatomy of a Generational Startup

MARTIN CASADO, MATT BORNSTEIN, SARAH WANG

The State of AI: Macro, Apps, and Consumer

ANISH ACHARYA, JEN KHA

The New Economics of AI | Martin Casado & Steven Sinofsky

BEN HOROWITZ, ERIK TORENBERG, MARTIN CASADO, STEVEN SINOFSKY, TRAVIS KALANICK

Why Medical AI Needs a Referee | Protege's Engy Ziedan

DAISY WOLF, ENGY ZIEDAN, EVA STEINMAN

Martin Casado on Where the Value Is Going in AI

MARTIN CASADO, SOPHIA DEW, THEO JAFFE

How Microsoft Is Securing the Agentic Enterprise | Aaron Zollman

AARON ZOLLMAN, JOEL DE LA GARZA

How Global Networks Are Reshaping Startup Success

ANGELA STRANGE, ELENA BURGER, GABRIEL VASQUEZ

How Whatnot Built a Global Marketplace

DAVID GEORGE, GRANT LAFONTAINE

How Do You Defend Against AI That Can Hack?

JOEL DE LA GARZA, MAX POLLARD, NICK WARNER

Stripe’s AI Strategy: Build More, Not Less

DAVID GEORGE, WILL GAYBRICK

Ben Horowitz and Travis Kalanick on Building Again

BEN HOROWITZ, ERIK TORENBERG, TRAVIS KALANICK

The Two Ways to Sell AI: Lighthouse or Landgrab?

ANDY MCCALL, ELENA BURGER, JOE SCHMIDT

The CISO Playbook for AI Agents | Datadog

EMILIO ESCOBAR, JOEL DE LA GARZA

How Kavak Rebuilt Itself Around AI Agents | Alejandro Maza Ayala

ALEJANDRO AYALA, ANGELA STRANGE, GABRIEL VASQUEZ

The Reality of AI-Powered Cyberattacks | Truffle Security & Socket

DYLAN AYREY, FEROSS ABOUKHADIJEH, HOST/INTERVIEWER, JOEL DE LA GARZA

How Open-Source AI Became Critical Infrastructure

ELENA BURGER, MATT BORNSTEIN, SIMON MO

Three Startups Reinventing Critical Infrastructure

DOUG BERNAUER, ERIK TORENBERG, ERIN PRICE-WRIGHT, TURNER CALDWELL, WILL O'BRIEN

OpenAI's Joshua Achiam: Did We Already Reach AGI?

JOSHUA ACHIAM, SEB CREAR, THEO JAFFEE

Ruby Thelot on Internet Culture, AI, and the Future of Taste

RUBY THELOT, SOFIA PUCCINI, SOPHIA DEW

Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation

CHRIS DIXON, MARC ANDREESSEN, ROBERT HACKETT

Decagon’s Playbook for Building Enterprise AI Applications

ASHWIN SRINIVAS, JESSE ZHANG, KIMBERLY TAN, SARAH WANG

AI for America's Small Businesses | Lassie

ALEX RAMPELL, FRÉDÉRIC RENKEN, OLIVIA MOORE, STEIJN PELLE

AI Micro Dramas, Generative Media, and the Future of Creativity

DAVID SACKS, JUSTINE MOORE

Fei-Fei Li on Spatial Intelligence and Robotics

FEI-FEI LI, MARTIN CASADO, YUNZHU LI

Steven Sinofsky: AI Doesn't Need New Rules Yet

SOFIA PUCCINI, STEVEN SINOFSKY, THEO JAFFEE

Ben Horowitz: The Fight Over Open Source AI

BEN HOROWITZ, SOFIA PUCCINI, THEO JAFFEE

Sriram Krishnan on Open Source AI's Biggest Week Yet

SOFIA PUCCINI, SRIRAM KRISHNAN, THEO JAFFEE, UNLABELED GUEST

Building the Physical AI Stack | Travis Kalanick on TBPN

JOHN COOGAN, JORDI HAYS, TRAVIS KALANICK, UNNAMED GUEST/CO-HOST, UNNAMED HOST/CO-HOST

Travis Kalanick Is Back | Building the Future of Industrial AI

BEN HOROWITZ, ERIK TORENBERG, TRAVIS KALANICK

Why Physical AI Is the Next Frontier | Applied Intuition

ERIK TORENBERG, MARC ANDREESSEN, PETER LUDWIG, QASAR YOUNIS

Hugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition

CLÉMENT DELANGUE, SOFIA PUCCINI, THEO JAFFEE

Amjad Masad on Going Direct, Building Replit, and the Future of Software

AMJAD MASAD, ERIK TORENBERG, UNIDENTIFIED CO-HOST/GUEST

Replay 2025: David Sacks on AI, Crypto, and America's Technology Future

BEN HOROWITZ, DAVID SACKS, ERIK TORENBERG, MARC ANDREESSEN

Can Anyone Catch NVIDIA? | The Future of Chips and Infrastructure

DYLAN PATEL, ERIK TORENBERG, ERIN PRICE-WRIGHT, GUIDO APPENZELLER

Is AI a Bubble? | Gavin Baker on Data Centers, GPUs, and the AI Economy

DAVID GEORGE, GAVIN BAKER, MODERATOR

Before Blockchains, There Was State Machine Replication

BARBARA LISKOV, ITAI ABRAHAM, TIM RUFFGARTEN

How Bitcoin Rewired a Classic Computer Science Problem

ITAI ABRAHAM, TIM RUFFGARTEN

Mark Zuckerberg & Priscilla Chan: How AI Will Help Cure Disease

BEN HOROWITZ, DR. PRISCILLA CHAN, ERIK TORENBERG, MARK ZUCKERBERG, UNIDENTIFIED, VINEETA AGARWALA

Adam Neumann: This Is How You Build Iconic Companies

ADAM NEUMANN, BEN HOROWITZ, ERIK TORENBERG, MARC ANDREESSEN, MARK ANDREESSEN

Is Software Losing Its Head?

A16Z HOST, ELENA BURGER, SEEMA AMBLE, STEVEN SINOFSKY

Don’t Follow Your Passion | Ben Horowitz’s Advice for New Graduates

A16Z HOST, BEN HOROWITZ

a16z Goes Global: Why American Tech Must Lead the World

ANNE NEUBERGER, BEN HOROWITZ, JEN KHA, RAGHU RAGHURAM

Outsmarting Uber: Why Bolt Wins in Europe

GABRIEL VASQUEZ, HOST/NARRATOR, MARKUS WILLIG

Rick Rubin on AI, Creativity, and The Way of Code

ANISH ACHARYA, BEN HOROWITZ, ERIK TORENBERG, MARC ANDREESSEN, RICK RUBIN

Building AI for Creators | Luma & Phota Labs

MATT TANCIK, YOKO LI, ZACH XIA

Beyond P(doom): Marc Andreessen - Betting on America

MARC ANDREESSEN, NAVIN GIRISHANKAR

AI Is Crossing the Frontier of Human Knowledge | Kevin Weil

KEVIN WEIL, SPEAKER_01, SPEAKER_02

Marc Andreessen on AI, Technology, and the Future of Humanity

MARC ANDREESSEN, MICHAEL MALICE

What Happens to Design After AI?

ANISH ACHARYA, JOHN MAEDA, PAUL BAKAUS

What’s Next for Consumer AI? | Josh Elman Joins a16z

ANISH ACHARYA, JOSH ELLMAN

Jake Paul & Anti Fund: From Creator to Investor

BALAJI SRINIVASAN, BENEDICT EVANS, CLEM DELANGUE, ERIK TORENBERG, GEOFF WOO, JAKE PAUL

The New Rules of Media | Marc Andreessen & Ben Horowitz

BEN HOROWITZ, ERIK TORENBERG, GABBY GOLDBERG, MARC ANDREESSEN

The Fintech Playbook for Latin America

ANGELA STRANGE, GABRIEL VASQUEZ, SANTIAGO SUÁREZ

Jack Altman on Product-Market Fit

AI, Design, and the Power of Open Models

A16Z PODCAST HOST, JUSTINE MOORE, MOHAMMAD NOROUZI, YOKO LI

Samo Burja on Growth, Energy, and AI

SAMO BURJA, THEO JAFFEE

Designing the Physical World with AI

ALEX MODON, DAVIDE ASNAGI, ERIN PRICE-WRIGHT

AI, Growth, and the Future of Healthcare | Anish Acharya & Sachin Jain

ANISH ACHARYA, SACHIN JAIN

Tyler Cowen & Alex Tabarrok on AI, Jobs, and Economic Growth

ALEX TABARROK, TYLER COWEN, WYATT THOMSON

Building Search for AI Agents with Exa CEO Will Bryk

A16Z PODCAST HOST, SARAH WANG, WILL BRYK

AI Agents and the Fight for Customer Data

GEORGE FRASER, MARTIN CASADO

AI Eats the World? A Reality Check with Benedict Evans

BENEDICT EVANS, ERIK TORENBERG

Balaji and Steven Glinert on Network States, Supply Chains, and Allied Coalition Strategy

BALAJI SRINIVASAN, SOPHIA PUCCINI, STEPHEN GLINERT, THEO JAFFEE

Steven Sinofsky on Apple at 50, Microsoft, and the Future of Computing

STEVEN SINOFSKY, THEO JAFFEE

Building AI Agents for Enterprise Operations

ANISH ACHARYA, LUIS PAARUP, OLIVIA MOORE, PABLO PALAFOX

Why $1B Exits are Dead

DAVID CLARK, DAVID GEORGE

Stablecoins, AI Agents, and The Future of Global Banking

ANGELA STRANGE, DALIP TASMAN

Marc Rowan on Private Markets, Software Repricing, and Capital Allocation

DAVID HABER, MARC ROWAN

Why AI Isn’t Killing SaaS Yet

ARA KARAZIAN, JACK FARLEY, MAX WHEATHEY

Hugging Face's Clem Delangue on Open Source AI and the LLM Bubble | MTS Live

CLEM DELANGUE, SOFIA PUCCINI, THEO JAFFEE

How Superhuman Took Over Silicon Valley Email

FAREED MOSAVAT, RAHUL VOHRA, SPEAKER 00

Marc Andreessen on AI, California, and the Future of America | Joe Rogan

JOE ROGAN, MARC ANDREESSEN

Rebuilding The American Shipyard

DINO MAVROOKAS, ERIN PRICE-WRIGHT, MICHAEL DUFFEY, MODERATOR

The Plan to Make American Crime Obsolete

COL. JEFFREY GLOVER, DAVID ULEVITCH, RAHUL SIDHU

Vitalik Buterin on Human Agency in the AI Era

BINJI PANDE, SOPHIA DEW, VITALIK BUTERIN

Ben Horowitz - "Your ONLY job is Right Product, Right Time"

BALAJI SRINIVASAN, BEN HOROWITZ

Energy, Minerals, and the Physical Stack Behind AI

DREW BAGLINO, ERIN PRICE-WRIGHT, TURNER CALDWELL

Balaji and Taylor Lorenz on AI and Media

A16Z NARRATOR, BALAJI SRINIVASAN, TAYLOR LORENZ, THEO JAFFEE

Workday’s Last Workday? AI and the Future of Enterprise Software

A16Z ANNOUNCER, ELENA BURGER, JOE SCHMIDT IV

The Shift in Global Drug Development

ANNOUNCER, CREMIEUX RECUEIL, GABRIEL DICKINSON, THEO JAFFEE

John and Patrick Collison on Stripe's Growth, Agent Commerce, and the Future of Software

A16Z NARRATOR, GEORGIE HAYES, JOHN COLLISON, PATRICK COLLISON, UNLABELED HOST/PARTICIPANT, UNLABELED PARTICIPANT

Ben Horowitz on Venture Capital and AI

ANJNEY MIDHA, ANNOUNCER / SHOW VOICE, BEN HOROWITZ, UNSPECIFIED (BRIEF SPEAKER)

AI Inside the Enterprise

A16Z ANNOUNCER, AARON LEVIE, ERIK TORENBERG, MARTIN CASADO, STEVEN SINOFSKY

Marc Andreessen: Monitoring the Situation and the Future of Media

ERIK TORENBERG, MARC ANDREESSEN

Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show

ANISH ACHARYA, ERIK TORENBERG, KEVIN ROSE, UNCREDITED PARTICIPANT

From Models to Mobility: Building Waymo with Dmitri Dolgov

A16Z PRODUCER / ANNOUNCER, DMITRI DOLGOV, JOHN COLLISON, UNLABELED SPEAKER / INTERJECTION

Technology, Culture, and the Next AI Interface with signüll

ANISH ACHARYA, ERIK TORENBERG, SIGNÜLL

Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI

AMJAD MASSAD, JACK NEEL, A16Z ANNOUNCER / NARRATOR

Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software

ALEX RAMPELL, BEN HOROWITZ, A16Z (ANNOUNCER/NARRATOR)

Building Agents at Home: Parenting, Work, and Benevolent Neglect

JESSE GENET, KATHERINE BOYLE, SARAH WANG, A16Z NARRATOR

What Running Windows at Microsoft Taught Steven Sinofsky About Apple

STEVEN SINOFSKY, THEO JAFFEE, A16Z (ANNOUNCER/NARRATOR)

Who Controls AI Acceleration? Vitalik Buterin and Guillaume Verdon Debate

ANNOUNCER / PRODUCER VOICE, EDDY LAZZARIN, GUILLAUME VERDON, SHAW WALTERS, VITALIK BUTERIN

The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie

AARON LEVIE, ERIK TORENBERG, MARTIN CASADO, STEVE SINOFSKY, A16Z (ANNOUNCER/NARRATOR)

Balaji on Why AI Raises the Cost of Verification

A16Z (ANNOUNCER/NARRATOR), BALAJI SRINIVASAN, ERIK TORENBERG, MILTON FRIEDMAN

Peter Yang on Small Teams, Coding Agents, and Why Human Ambition Has No Ceiling

ANISH ACHARYA, PETER YANG, A16Z (ANNOUNCER/NARRATOR)

Marc Andreessen on AI Winters and Agent Breakthroughs

ALESSIO FANELLI, ANNOUNCER / EPISODE INTRO, INTERRUPTION / BRIEF INTERJECTION, MARC ANDREESSEN, SWYX (SHAWN WANG)

Alex Blania on Proof of Human and Building World's Identity Network

ALEX BLANIA, BEN HOROWITZ, ERIK TORENBERG

What Happens When a Public Company Goes All In on AI

A16Z (ANNOUNCER/NARRATOR), DAVID HABER, OWEN JENNINGS

How Radiant and Heron Are Rethinking Power Generation and Delivery

DOUG BERNAUER, DREW BAGLINO, ERIK TORENBERG, ERIN PRICE-WRIGHT, NARRATOR / A16Z PRODUCTION

Marc Andreessen on Evaluating Founders and AI's Consumer Surplus

A16Z NARRATOR, HARRY STEBBINGS, MARC ANDREESSEN

The SpaceX and Tesla Playbook for Hard Tech Startups

CHANDLER LUJICA, ERIN PRICE-WRIGHT, TURNER CALDWELL, UNLABELED PARTICIPANT, A16Z ANNOUNCER

Security, Resilience, and the Future of Mobile Infrastructure

DAVID ULEVITCH, JOHN DOYLE, JUSTIN FANELLI, UNIDENTIFIED INTERJECTION, A16Z (ANNOUNCER/NARRATOR)